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CVCs optimally locked with the 3-in-1 catheter lock solution 5. ok

  • Neutrolin is an antimicrobial and anticoagulant catheter lock solution for hemodialysis patients. Neutrolin provides protection against catheter-related bloodstream infections (CRBSI) and for maintenance of catheter patency.
  • Neutrolin contains: 1,000 IE/ml heparin; 3.50 % citrate and 1.35 % taurolidine.

Why Neutrolin ?

  • Higher degree of safety for processes and more reliability of treatment schedules in the daily routine.
  • Reduction of additional treatment costs (e.g. urokinase).
  • Increased patient satisfaction by prevention of complication related delays.
  • Increasing quality of dialysis treatment.
  • (HD-access related infections are a benchmark parameter for the quality guideline dialysis).

Catheter lock solution taurolidine, heparin and citrate

First-in-class, non-antibiotic solution that prevents infections and thrombosis associated with central venous catheters.

Neutrolin® consists of taurolidine 1.35 %, heparin 1,000 units/mL and citrate 3.5 % :

  • Taurolidine 1.35 % is a synthetic broad-spectrum anti-bacterial and anti-fungal compound that is metabolized to the amino acid taurine in humans, which limits its  toxicity for clinical use.
  • Heparin 1,000 units/mL is added to Neutrolin as a well-established anticoagulant.
  • Citrate 3.5 % is added as a buffer to ensure that taurolidine remains in solution at ~ pH 6.

Neutrolin® is an antimicrobial and anticoagulant catheter lock solution for hemodialysis patients.

Neutrolin provides protection against catheter-related blood stream infections (CRBSI) and helps  to maintain catheter patency.

Attributes of Neutrolin which improve lock effectiveness2 :

  • Broad-spectrum antimicrobial effect against bacteria and fungi.
  • Safe and compatible with tissue and blood.
  • No evidence of bacterial resistance in human.
  • No systemic pharmacological effect.
  • Inactivation of endotoxin.
  • Reduces adherence of bacteria and blood to surfaces.

Active ingredient – taurolidine

  • Taurolidine is a unique nontoxic substance that eliminates binding of bacteria and some fungi  to the surface.
  • Taurolidine is NOT an antibiotic and it has never demonstrated bacterial resistance.
  • Taurolidine is a broad-spectrum antimicrobial active substance against virulent bacteria and fungi,  responsible for most HD infections.
  • Taurolidine has proven effective in preventing catheter colonization at the planktonic level  and eradication of a developed biofilm in several types of in vitro tests.